IVF with Preimplantation Genetic Testing [6 Commonly Asked Questions]
Building a family may present challenges for you, or you might be concerned about conceiving a healthy child. IVF with preimplantation genetic testing may be a good option.
Here are six commonly asked questions about this testing to help you learn what it is and whether it’s right for you.
What Is Preimplantation Genetic Testing?
Preimplantation genetic testing (PGT) involves removing one or more cells from an embryo, via a biopsy. These cells provide information regarding the chromosome makeup of your embryo and may also detect rare genetic disorders.
PGT is performed before embryo transfer during the IVF process.
What Is the Purpose of IVF with Genetic Testing?
With genetic testing, you can:
- Assess possible genetic conditions or chromosome abnormalities in your embryo cells.
- Gain insight into the cause of frequent miscarriages or previously unsuccessful IVF cycles.
Chromosomal abnormalities account for the vast majority of all miscarriages. Therefore, PGT greatly reduces the chance of miscarriage—it improves the odds of IVF success by selecting an embryo with normal chromosomes for transfer.
Is Genetic Testing Necessary with IVF?
Genetic testing is not necessary with IVF—it’s optional.
PGT can be especially beneficial for those with inherited familial diseases who want to see if their child would have the same condition.
Examples of these disorders include:
- Single-gene disorders (e.g., cystic fibrosis, sickle cell anemia)
- Genetic disorders (e.g., Fragile X syndrome)
- Musculoskeletal disorders (e.g., Duchenne muscular dystrophy)
What Are the Different Variations of PGT Available?
There are three main variations of PGT available:
- PGT for aneuploidy (PGT-A): This exam screens for extra or missing chromosomes.
- PGT for monogenic disorders (PGT-M): PGT-M looks for specific gene mutations the embryo may be at risk of inheriting (i.e. cystic fibrosis).
- PGT for structural rearrangements (PGT-SR): This exam is performed when you or your partner carries a rearrangement of their own chromosomes (e.g., translocation or inversion). These rearrangements can lead to producing embryos that are chromosomally abnormal.
What Is the Cost of Embryo Genetic Testing?
PGT may cost anywhere from $1,800 - $6,000. The cost varies depending on the clinic, testing company, and how many embryos are being tested.
How Do You Know If Embryo Genetic Testing Is Right for You?
As every patient’s IVF journey is different, we recommend speaking with your fertility specialist about PGT.
According to Johns Hopkins Medicine, good candidates for PGT typically comprise:
- Women over the age of 37
- Those who are at risk of having a child impacted with an inherited genetic disease
- History of recurrent miscarriages
Learn More from Future Family
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In the meantime, we encourage you to look into these helpful IVF resources: